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KMID : 1161519970010020337
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Animal Cells and Systems
1997 Volume.1 No. 2 p.337 ~ p.340
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Reducing fetal contamination of radiostrontium by water soluble chitosan
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Kim Young-Ho
Roh Young-Bok
Kim Kwang-Yoon
Bom Hee-Seung
Kim Ji-Yeul
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Abstract
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The purpose of this study is to evaluate whether water soluble chitosan, a natural nontoxic chelator, can reduce fetal contamination of radiostrontium in pregnant mice. Various forms of water soluble chitosans (10% or 1% powder, or 1% solution) were given to pregnant mice before or after contamination of 0.005 μCi/B.W(g) Sr?85. Transplacental transfer of Sr?85 to fetus was 6.8±2.7% of injected dose, when Sr?85 was administered at the 20th day of pregnancy. Fetal radioactivity was significantly reduced when mother mice were treated with water soluble chitosan before contamination of Sr?85. Water soluble chitosans of 10% or 1% powder, or 1% solution significantly reduced fetal retention of Sr?85 to 2.3±0.7%, 2.7±0.8%, and 2.0±0.9%, respectively. However, fetal contamination was not reduced, when water soluble chitosans of 10% or 1% powder, or 1% solution were administered after maternal contamination of Sr?85. From these data we can conclude that water soluble chitosan could reduce fetal contamination of radiostrontium in pregnant mice, when given before the pregnant mice were exposed to radiostrontium.
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KEYWORD
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Pregnancy, Mouse, Chitosan, Radiostrontium, Chelator
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